How to distinguish monophasic、biphasic and multiphasic hyaluronic acid?

Understanding Hyaluronic Acid

Before diving into the different formulations, let’s briefly recap what hyaluronic acid is:

• A naturally occurring glycosaminoglycan in the skin.
• Capable of holding up to 1,000 times its weight in water, making it a powerful hydrator.
• Used in serums, fillers, and moisturizers to plump skin, reduce wrinkles, and improve elasticity.

Now, let’s explore the three main types of HA formulations.

Monophasic Hyaluronic Acid

Definition:

Monophasic HA consists of a single-phase formulation, meaning it contains hyaluronic acid in one uniform consistency.

Characteristics:

✔ Single molecular weight (usually low or medium).

✔ Lightweight texture, easily absorbed.

✔ Ideal for surface hydration rather than deep volumizing.

Best For:

• Daily moisturizing serums.
• Hydrating toners or essences.
• Sensitive or acne-prone skin (due to its simple formulation).

How to Identify It:

Check the ingredient list for "sodium hyaluronate" or "hydrolyzed hyaluronic acid" (common in monophasic products).

The product will have a thin, watery consistency.

Biphasic Hyaluronic Acid

Definition:

Biphasic HA combines two different molecular weights (e.g., low and high) in one product, offering dual-action hydration.

Characteristics:

✔ Two-phase system:

• High-molecular-weight HA sits on the skin’s surface for immediate plumping.
• Low-molecular-weight HA penetrates deeper for long-term hydration.

✔ Often found in advanced serums and fillers.

Best For:

Anti-aging treatments (reduces fine lines and improves elasticity).

Combination skin (balances surface and deep hydration).

Post-procedure skincare (supports skin recovery).

How to Identify It:

Look for terms like "cross-linked HA" or "dual/multi-weight hyaluronic acid".

The product may have a slightly thicker, gel-like texture compared to monophasic HA.

Multiphasic Hyaluronic Acid

Definition:

Multiphasic HA is the most complex and combines three or more molecular weights, along with additional active ingredients (e.g., peptides, antioxidants).

Characteristics:

✔ Multi-layered hydration:

• Ultra-low MW HA penetrates deeply into the dermis.
• Medium MW HA hydrates the mid-layers.
• High MW HA creates a moisture barrier on the surface.

✔ Often enhanced with growth factors, vitamins, or collagen boosters.

Best For:

Mature skin needing intensive repair.

Medical-grade skincare and professional treatments.

Long-term anti-aging regimens.

How to Identify It:

The label may mention "triple/multi-weight HA" or "hyaluronic acid complex".

Often found in luxury serums, ampoules, or dermal fillers.

Conclusion

Understanding the differences between monophasic, biphasic, and multiphasic hyaluronic acid ensures you select the most effective product for your skincare needs. Whether you need light hydration, dual-action plumping, or advanced anti-aging benefits, there’s an HA formulation designed for you.